Purdue Research Foundation receives multiple patents for miniature chemical analysis

Published: June 9, 2014

WEST LAFAYETTE, Ind. - Purdue Research Foundation (PRF) received patents in two categories of analytical chemistry that enable the longstanding research and development of miniature mass spectrometry in the laboratories of Purdue University researchers R. Graham Cooks and Zheng Ouyang. Recently allowed and soon to issue, is U.S. Application Serial Number 14/010,130, is directed to low temperature plasma ionization probes that are useful for direct ionization of samples at standard temperature and pressure. Because of the low temperature used, relative to high temperature equilibrium plasmas, this patented invention does not breakdown molecules so the molecular information is retained in the ions produced. U.S. 8,519,354 is directed to methods that are useful for direct ionization of samples at standard temperature and pressure. The patented methods include in situ chemical synthesis and analysis of a sample in one-step. The advantage is shorter analysis times and no sample preparation. These patents add to the robust PRF patent portfolio of ambient sample ionization systems and methods. 

PRF also received U.S. 8,304,718 and Chinese patent application number 200880101096.3 directed to a critical component of a miniature mass spectrometry system, known as a discontinuous sample introduction interface. Using a discontinuous sample introduction interface in a benchtop or miniature system reduces the energy requirements by functioning at a low pressure while enhancing transfer efficiency of ions to regions of reduced pressure. Discontinuous sample gas introduction is important in down-sized mass spec systems, such as a portable mass spectrometer, to avoid sample overload and achieve desired sensitivity.

For information, contact jdgortat@prf.org or 765-588-3475.